The species-specific genotyping plugins (for Escherichia coli, Listeria monocytogenes, Salmonella enterica and Staphylococcus aureus) and the generic resistance detection plugin download their knowledge bases from the BIONUMERICS support website. After December 31st 2024, when the support website is taken offline, existing genotyping plugin installations will continue working with the same knowledge bases, but error messages might pop up if the plugin checks for updates online. For new genotyping plugin installations, an archive with all online knowledge bases should be downloaded and the corresponding knowledge bases installed manually. Please note that the ZIP archive only contains knowledge bases compatible with BIONUMERICS version 8.1, so make sure to have the latest software version installed.
Existing genotyping plugin installations:
- Open the genotyping plugin settings dialog and uncheck for each knowledge base the option "Check for updates on startup" and press <OK>.
You can keep working with the genotyping plugin with the same knowledge bases.
New installations of a genotyping plugin:
- Download the ZIP archive containing all online genotyping knowledge bases. Unzip the archive to a location on your hard drive. The "knowledgebases" base directory contains five subdirectories: GenotypingEcoli2, GenotypingListeria, GenotypingResistance, GenotypingSalmo, and GenotypingStaph for the Escherichia coli, Listeria monocytogenes, resistance detection, Salmonella enterica and Staphylococcus aureus genotyping plugin, respectively.
- Proceed with the plugin installation as usual. Several urlopen errors will appear "The server name or address could not be resolved" because the plugin tries to download its knowledge bases from the now offline website.
- Answer "No" to the question "Do you want to change the 'Listeria' genotyping settings now?"
- Close the BIONUMERICS database.
- Locate the source files directory for your database (the default location is the sourcefiles subfolder of the database directory). In the source files directory, there will be a directory called "GenotypingKnowledgebases" with a subdirectory that corresponds to the plugin you are installing (e.g., for the Listeria monocytogenes genotyping plugin, a directory "GenotypingListeria" will have been created by the plugin). Copy the content from the corresponding directory in the unzipped archive to the plugin folder in the source files directory.
- Open the BIONUMERICS database again.
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Open the genotyping settings. For each analysis that you want to perform, take following steps:
- Press the <Change…> button to change the knowledge base.
- In the dialog that pops up, highlight the preferred knowledge base and press <OK>.
- Press <OK> in the genotyping settings dialog.
The genotyping plugin is now ready for use.